Mitochondrial dynamic modulators improve cognitive function in rats with myocardial infarction

Background Cognitive impairment is the most frequent mental health problem among people with heart failure (HF). Brain pathologies in HF-induced cognitive are possibly associated imbalance of brain mitochondrial dynamics. Therefore, therapeutic interventions targeting dynamics by fission inhibition or fusion enhancement would provide beneficial outcomes to HF subjects. This study aimed test whether modulating dynamic improves function rats via reduced dysfunction, and dendritic spine loss. Method Rats underwent either sham surgery permanent left anterior descending coronary artery ligation-induced myocardial infarction (MI). MI developed ejection fraction (%LVEF <50%) at 1-week post-operation. Then, were assigned receive one four following interventions: (1) DMSO as a vehicle, (2) enalapril (a positive control, 10 mg/kg/day, orally), (3) division Inhibitor (Mdivi-1, 1.2 intraperitoneal (IP) injection), (4) promotor (M1, 2 IP injection). All received intervention for 4 weeks, then, NOL was assessed, sacrificed. density determined. Result impairment, when compared group, it increased oxidative stress, loss hippocampus (Figure). Treatment Mdivi-1 M1 improved similar enalapril, indicated increasing %preference NOL. Furthermore, all treatments effectively ROS levels hippocampal Conclusion Mitochondrial inhibitor through reduction preserved density.